abstract：:Schizophrenia patients have higher scores on neurological soft-signs (NSS) and show greater deficits on a variety of neuropsychological tests than normal control subjects and mixed groups of psychiatric patients. Among chronic schizophrenia patients it is unclear which of these types of deficits most strongly differen...

journal_title：Schizophrenia bulletin

authors： Smith RC,Kadewari RP,Rosenberger JR,Bhattacharyya A

更新日期：1999-01-01 00:00:00

abstract：:Considerable research has documented the stigmatization of people with mental illnesses and its negative consequences. Recently it has been shown that stigma may also seriously affect families of psychiatric patients, but little empirical research has addressed this problem. We examine perceptions of and reactions to ...

journal_title：Schizophrenia bulletin

authors： Phelan JC,Bromet EJ,Link BG

更新日期：1998-01-01 00:00:00

abstract：:Clozapine has been found to be superior to traditional neuroleptics in the treatment of refractory schizophrenia and is increasingly being used to treat schizophrenia, affective disorders, some neurological disorders, and aggression. For many patients, clozapine offers new hope for the successful pharmacological manag...

journal_title：Schizophrenia bulletin

authors： Young CR,Bowers MB Jr,Mazure CM

更新日期：1998-01-01 00:00:00

abstract：:The validity of a Hindi version of the Diagnostic Interview for Genetic Studies (DIGS) was investigated. The original English version was initially translated into Hindi. The Hindi version was then back-translated and compared with the original. Next, a group of psychiatric inpatients and outpatients were interviewed ...

journal_title：Schizophrenia bulletin

authors： Deshpande SN,Mathur MN,Das SK,Bhatia T,Sharma S,Nimgaonkar VL

更新日期：1998-01-01 00:00:00

abstract：:A series of human and animal investigations has suggested that altered expression and function of the alpha7-nicotinic cholinergic receptor may be responsible for the auditory sensory gating deficit characterized in schizophrenia patients and their relatives as diminished suppression of an auditory-evoked response (P5...

journal_title：Schizophrenia bulletin

authors： Adler LE,Olincy A,Waldo M,Harris JG,Griffith J,Stevens K,Flach K,Nagamoto H,Bickford P,Leonard S,Freedman R

更新日期：1998-01-01 00:00:00

abstract：:This meta-analytic review sought to answer questions concerning the role of psychosocial treatments in the comprehensive management of patients with schizophrenia. The review focused on the effects of combining psychosocial treatment with somatic treatment. Findings demonstrated the additive and supplementary effects ...

journal_title：Schizophrenia bulletin

authors： Mojtabai R,Nicholson RA,Carpenter BN

更新日期：1998-01-01 00:00:00

abstract：:The relationship between a history of substance use disorder and the early course of psychotic illness was examined in 96 subjects with schizophrenia and 106 subjects with affective psychosis followed in the Suffolk County Mental Health Project, a longitudinal study of first-admission psychosis. Subjects received a st...

journal_title：Schizophrenia bulletin

authors： Kovasznay B,Fleischer J,Tanenberg-Karant M,Jandorf L,Miller AD,Bromet E

更新日期：1997-01-01 00:00:00

abstract：:In a previous article in the Schizophrenia Bulletin (Vol. 22, No. 1, 1996), we presented findings of a study on the clinical and rehabilitative effects of work activity on 150 subjects diagnosed with schizophrenia or schizoaffective disorder. Subjects were randomly assigned to either a Pay ($3.40/hr) or No-Pay group a...

journal_title：Schizophrenia bulletin

authors： Bell MD,Lysaker PH

更新日期：1997-01-01 00:00:00

abstract：:Advances in psychopharmacology have produced medications with substantial efficacy in the treatment of positive and negative symptoms of schizophrenia and the prevention of relapse or symptom exacerbation after an acute episode. In the clinical setting, the individual patient's acceptance or rejection of prescribed ph...

journal_title：Schizophrenia bulletin

authors： Fenton WS,Blyler CR,Heinssen RK

更新日期：1997-01-01 00:00:00

abstract：:A substantial amount of research has focused on the midbrain dopamine system and its role in emotional and motivational behaviors. In diseases in which dopamine function is compromised, patients exhibit a constellation of symptoms, suggesting that the dopamine system plays an important role in the integration of sever...

journal_title：Schizophrenia bulletin

authors： Haber SN,Fudge JL

更新日期：1997-01-01 00:00:00

abstract：:Many brain regions and circuits have been implicated in the neuropathology of schizophrenia. Drs. Bogerts and Jones have reviewed the evidence that links the disorder to temporal limbic structures and to frontal-thalamic circuits, respectively. Each article is an important update on what we know about the relevance of...

journal_title：Schizophrenia bulletin

authors： Weinberger DR

更新日期：1997-01-01 00:00:00

abstract：:This study tested hypothesized relationships between neuropsychological and psychophysiological variables and concurrent levels of clinical and psychosocial functioning in schizophrenia. The sample consisted of 40 subjects diagnosed with a chronic schizophrenia spectrum disorder and living in community-based settings....

journal_title：Schizophrenia bulletin

authors： Brekke JS,Raine A,Ansel M,Lencz T,Bird L

更新日期：1997-01-01 00:00:00

abstract：:Neuroleptic drugs block brain dopamine receptors and are effective in treating psychoses of diverse origins. This finding has become a cornerstone of the dopamine theory of schizophrenia, but clinical studies relating schizophrenia, per se, to brain dopamine metabolism have ranged from controversial to negative. This ...

journal_title：Schizophrenia bulletin

authors： Maas JW,Bowden CL,Miller AL,Javors MA,Funderburg LG,Berman N,Weintraub ST

更新日期：1997-01-01 00:00:00

abstract：:The poverty and lack of social role in the lives of many people with schizophrenia seem similar to those of people in long-term unemployment, raising the possibility that there may be some commonalities in their time use and community functioning. To test this possibility, the social anxiety, time use, and activity pa...

journal_title：Schizophrenia bulletin

authors： Hayes RL,Halford WK

更新日期：1996-01-01 00:00:00

abstract：:There is some support for the hypothesis that the factor structure of schizophrenia symptoms is similar to the factor structure of schizotypal symptoms in nonschizophrenia populations. However, no studies to date have examined schizotypal symptoms in patients with personality disorders. In this study, confirmatory fac...

journal_title：Schizophrenia bulletin

authors： Bergman AJ,Harvey PD,Mitropoulou V,Aronson A,Marder D,Silverman J,Trestman R,Siever LJ

更新日期：1996-01-01 00:00:00

abstract：:Recently published data from the Roscommon Family Study show that a parental diagnosis of schizotypal disorder (SPD) has a significant and specific impact on the risk for schizophrenia in siblings of index probands with schizophrenia spectrum disorders. The distribution patterns of risks for schizophrenia and SPD in p...

journal_title：Schizophrenia bulletin

authors： Battaglia M,Bellodi L

更新日期：1996-01-01 00:00:00

abstract：:Secondary prevention in schizophrenia is still not good enough, and the authors of the articles in this issue of Schizophrenia Bulletin present important new knowledge that may increase earlier detection and treatment. This final article discusses some of their main findings in relation to clinical consequences and ne...

journal_title：Schizophrenia bulletin

authors： Vaglum P

更新日期：1996-01-01 00:00:00

abstract：:Cognitive models of interpersonal problem solving have been proposed for, but infrequently tested on, samples of schizophrenia subjects. This study undertook to examine the relationships between the receiving, processing, and sending skills that comprise one model of interpersonal problem solving with information proc...

journal_title：Schizophrenia bulletin

authors： Corrigan PW,Toomey R

更新日期：1995-01-01 00:00:00

abstract：:We report a 25-year followup of a group of 50 children at genetic risk for schizophrenia (by virtue of having a parent with the disorder) and 50 matched controls. The children who eventually developed schizophrenia spectrum disorders, including schizophrenia, were identifiable by cognitive-psychophysiological, neuroin...

journal_title：Schizophrenia bulletin

authors： Mirsky AF,Kugelmass S,Ingraham LJ,Frenkel E,Nathan M

更新日期：1995-01-01 00:00:00

abstract：:With on exception, previous studies examining the familial relationship between schizotypal personality disorder (SPD) and schizophrenia have compared rates of SPD in relatives of probands with schizophrenia versus control probands. In the Roscommon Family Study, an epidemiologically based family study of major psychi...

journal_title：Schizophrenia bulletin

authors： Kendler KS,Walsh D

更新日期：1995-01-01 00:00:00

abstract：:This article reviews the existing evidence for the efficacy and effectiveness of psychoeducational family interventions in the treatment of persons with schizophrenia. There is substantial evidence that psychoeducational family interventions reduce the rate of patient relapse. There is suggestive, though not conclusiv...

journal_title：Schizophrenia bulletin

authors： Dixon LB,Lehman AF

更新日期：1995-01-01 00:00:00

abstract：:Descriptions of various psychotic symptoms in children began to appear in the psychiatric literature at about the same time as descriptions of psychotic symptoms in adults. For example, Kraepelin estimated that at least 3.5 percent of his cases of dementia praecox had onsets before age 10. The construct of "childhood ...

journal_title：Schizophrenia bulletin

authors： Asarnow RF,Asarnow JR

更新日期：1994-01-01 00:00:00

abstract：:Family studies of schizophrenia frequently include relatives of schizophrenia probands with diagnoses falling within the schizophrenia spectrum. As part of an ongoing genetic linkage study of schizophrenia, the authors examined case material from 50 relatives (of schizophrenia probands) who received a DSM-III-R diagno...

journal_title：Schizophrenia bulletin

authors： Gladis MM,Levinson DF,Mowry BJ

更新日期：1994-01-01 00:00:00

abstract：:The psychometric high-risk strategy represents a useful methodologic adjunct to the traditional genetic high-risk research approach in the study of the etiology and development of schizophrenia. During the past 15 years, considerable research activity has focused on psychometrically identified individuals hypothesized...

journal_title：Schizophrenia bulletin

authors： Lenzenweger MF

更新日期：1994-01-01 00:00:00

abstract：:Impaired attention is commonly observed among schizophrenia patients and those at genetic risk for the disease. This article reviews over 40 studies that used various versions of the Continuous Performance Test (CPT) as the primary measure of attention. These studies of normal subjects, affected patients, and various ...

journal_title：Schizophrenia bulletin

authors： Cornblatt BA,Keilp JG

更新日期：1994-01-01 00:00:00

abstract：:As part of an open clinical trial currently underway at the Max Planck Institute of Psychiatry in Munich, the feasibility of behavioral family management (Falloon et al. 1984) for schizophrenia in combination with two different neuroleptic medication strategies was investigated. The treatment approaches were psychoedu...

journal_title：Schizophrenia bulletin

authors： Wiedemann G,Hahlweg K,Hank G,Feinstein E,Müller U,Dose M

更新日期：1994-01-01 00:00:00

abstract：:We reported previously that residents of Greater Helsinki, Finland, whose mothers were exposed to the 1957 influenza epidemic during their second trimester of gestation had a significantly elevated risk of developing adult schizophrenia. The majority of the replication studies to date have not determined whether the m...

journal_title：Schizophrenia bulletin

authors： Mednick SA,Huttunen MO,Machón RA

更新日期：1994-01-01 00:00:00

abstract：:Medical geology is the application of trace element geography to epidemiology. This approach is used to compare the geographic distribution of selenium and other trace elements in soil and food with that of high schizophrenia rates in the United States and other countries. Since the comparison is most statistically si...

journal_title：Schizophrenia bulletin

authors： Brown JS Jr

更新日期：1994-01-01 00:00:00

abstract：:The issue of specificity of delusions in schizophrenia is still a matter of debate. The authors analyze the delusion formation in schizophrenia from a prototypical, phenomenological point of view, focusing on the subject's experience. This perspective links delusion formation to the autistic predisposition, which is c...

journal_title：Schizophrenia bulletin

authors： Bovet P,Parnas J

更新日期：1993-01-01 00:00:00

abstract：:We report an analysis of a large catchment area sample of patients with nonaffective functional psychoses presenting across all ages at onset. The male:female ratio was 1.56:1 in the 16-25-year age group; it reached unity around 30 years of age and declined to 0.38:1 in the 66-75-year group. Contrary to expectation, a...

journal_title：Schizophrenia bulletin

authors： Castle DJ,Murray RM

更新日期：1993-01-01 00:00:00

abstract：:This study examined the course of illness and factors affecting it in schizophrenias with onset between the ages of 14 and 18. Noteworthy in comparison to findings from other followup studies is the higher proportion of chronic courses of illness, about 50 percent. In addition, the type of course of illness correspond...

journal_title：Schizophrenia bulletin

authors： Krausz M,Müller-Thomsen T

更新日期：1993-01-01 00:00:00

abstract：:The article that follows is part of the Schizophrenia Bulletin's ongoing First Person Accounts series. We hope that mental health professionals--the Bulletin's primary audience--will take this opportunity to learn about the issues and difficulties confronted by consumers of mental health care. In addition, we hope tha...

journal_title：Schizophrenia bulletin

authors： Bowden WD

更新日期：1993-01-01 00:00:00

abstract：:Ventricle-to-brain ratio (VBR) was measured from the computed tomographic (CT) scans of 33 very recent-onset psychotic patients. Illness severity and positive and negative symptoms were also assessed in 21 of these patients with schizophreniform disorder. Forty-five neurology patients served as controls. Analyses reve...

journal_title：Schizophrenia bulletin

authors： Holsenbeck LS 3rd,Davidson LM,Hostetter RE,Casanova MF,Taylor DO,Kelley CT,Perrotta C Jr,Borison RL,Diamond B

更新日期：1992-01-01 00:00:00

abstract：:The chronic methamphetamine (MAP) intoxication model of schizophrenia in animals is outlined. The idea originated from the clinical and neurochemical similarities between MAP psychosis and schizophrenia that were found during the decade immediately after World War II when MAP abuse occurred in epidemic proportions in ...

journal_title：Schizophrenia bulletin

authors： Machiyama Y

更新日期：1992-01-01 00:00:00

abstract：:The apparent neglect of neuropsychologic deficits in schizophrenia as the basis for therapeutic intervention, together with only isolated attempts at remediating them, probably reflect the nature of impairments, the functional significance of which is uncertain. A critique of the limitations inherent in the appealing ...

journal_title：Schizophrenia bulletin

authors： Hogarty GE,Flesher S

更新日期：1992-01-01 00:00:00

abstract：:This analysis examines the notion of progressive deterioration in schizophrenia, using long-term followup data on hospital episodes in defined cohorts from psychiatric case registers in Victoria, Australia; Denmark; and Salford, England. The analyses differentiate heterogeneity existing at the first hospitalization fo...

journal_title：Schizophrenia bulletin

authors： Eaton WW,Bilker W,Haro JM,Herrman H,Mortensen PB,Freeman H,Burgess P

更新日期：1992-01-01 00:00:00

abstract：:Given the rising costs of health care and the decrease in public expenditures on mental health care, policy-makers and program managers must identify cost-effective approaches for treating severely mentally ill patients. During the last year, there have been two major cost-effectiveness studies implemented in Californ...

journal_title：Schizophrenia bulletin

authors： Hu TW,Jerrell J

更新日期：1991-01-01 00:00:00

abstract：:In this issue we have tried to bring together a series of reviews describing new developments in the pharmacologic management of schizophrenia. Important progress is being made not only in medication development, but also in furthering our ability to use available treatments and treatment combinations in the most effe...

journal_title：Schizophrenia bulletin

authors： Kane JM

更新日期：1991-01-01 00:00:00

abstract：:The clinical importance of subtypes based on enduring deficit or negative symptoms was examined in a group of schizophrenic patients who were assessed twice over a 1-year period. Subgroups of patients with high levels of enduring negative or deficit symptoms, based on the Scale for the Assessment of Negative Symptoms ...

journal_title：Schizophrenia bulletin

authors： Mueser KT,Douglas MS,Bellack AS,Morrison RL

更新日期：1991-01-01 00:00:00

abstract：:Given the variety of "organic" or "toxic" conditions that may produce, precipitate, or exacerbate psychotic disorders, it is important to attempt to clarify existing nosologies and to highlight the need for research strategies that may help to validate relevant distinctions. This review provides a brief discussion of ...

journal_title：Schizophrenia bulletin

authors： Kane JM,Selzer J

更新日期：1991-01-01 00:00:00